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27th International Winter-Workshop

Clinical, Chemical & Biochemical

Aspects of Pteridines



The International Society of Pteridinology

in collaboration with the

Austrian Society of Laboratory Medicine and Clinical Chemistry


March 2nd - 9th, 2008, St.Christoph/Arlberg, Austria



Location:                            Arlberg Hospiz Hotel

Scientific Committee:       Fuchs D (Innsbruck), Köller U (Vienna), Reibnegger G (Graz)        

Honorary Committee:       Curtius HCh (Zurich, Radolfzell-Böhringen), Pfleiderer W (Konstanz), Wachter H (Innsbruck)

Language:                         The official conference language is English

Presentation:                    Beamer (PC, Windows only)

Lectures:                           20 minutes (including 5 minutes for discussion)

Publication:                       Abstracts will be published in PTERIDINES

All scientific sessions take place at the SEMINAR ROOM Heinrich Findelkind.

Sunday, March 2nd, 2008

7:00 p.m.        Welcome Cocktail at the Chimney-Hall, Arlberg-Hospiz Hotel

                        Thereafter, dinner will be served at the BRUDERSCHAFTSSTUBE


Monday, March 3rd, 2008                                                  3:15 p.m. - 6:35 p.m.: Scientific Sessions

3:15 – 4:40      Chair: Sperner-Unterweger B (Innsbruck, Austria)

3:15     Introduction

            Fuchs D (Innsbruck, Austria)

3:25    Psychiatric symptoms and biological parameters in patients with ovarian cancer

            Sperner-Unterweger B, Kohl C, Grahmann A, Meraner V, Zeimet A, Fuchs D (Innsbruck,


3:45     Quality of life and immune-mediated tryptophan degradation in patients with bronchial carcinoma

            Schroecksnadel K, Pircher M, Fiegl M, Weiss G, Denz H, Fuchs D (Innsbruck & Natters,  Austria)

4:05     Free radicals in the striatum of the mouse after LPS-stimulation

            Clement HW, Heiser P, Sommer O, Schulz E, von Dobschuetz E (Freiburg, Germany)

4:25    The mild encephalitis hypothesis of major psychiatric disorders and associated treatment approach

            Bechter K (Günzburg, Germany)

4:45 – 5:15      Coffee Break


5:15 – 6:35      Chair: Weiss G (Innsbruck, Austria)

5:15     Role of interferon-g for the control of Chlamydia pneumoniae infections

            Martinz V, Bellmann-Weiler R, Schroecksnadel K, Fuchs D, Weiss G (Innsbruck, Austria)

5:35     Role of Nramp1 in Salmonella infection

            Nairz M, Fritsche G, Mair S, Schroll A, Bellmann-Weiler R, Barton H, Weiss G (Innsbruck, Austria)

5:55     TIM proteins at the interface of iron homeostasis and cellular immunity

            Schroll A, Nairz M, Seifert M, Moschen A, Theurl M, Mair S, Weiss G (Innsbruck, Austria) 

6:15     Effects of proton pump inhibitors on DMT-1 funtion

            Mair S, Ludwiczek S, Theurl I, Nairz M, Schwelberger M, Weiss H, Jakab M, Ritter M, Muckenthaler M, Hentze

            MW, Weiss G (Innsbruck & Salzburg, Austria; Heidelberg, Germany)

Tuesday, March 4th, 2008                            9:00 a.m. - 1:00 p.m.: Meet the Experts

                                                                                                   3:15 p.m. - 6:40 p.m.: Scientific Sessions

3:15 – 4:35      Chair:
Sedlmayr P (Graz, Austria)

3:15     Vascular endothelial expression of indoleamine 2,3-dioxygenase at the feto-maternal    interface

            Blaschitz A, Gauster M, Lang I, Dohr G, Takikawa O, Fuchs D, Sedlmayr P (Graz & Innsbruck, Austria; Obu 

            City, Japan)

3:35     Importance of immunological parameters for risk adjustment and stratification of surgical patients

            Engin AB, Engin A, Sepici-Dincel A, Kurukahvecioglu O (Ankara, Turkey)

3:55     Increase of homocysteine concentrations in trauma and sepsis patients

            Neurauter G, Ploder M, Spittler A, Schroecksnadel K, Pelinka L, Roth E, Fuchs   D (Innsbruck & Vienna, 


4:15     Relationship between serum neopterin, folate, homocysteine, vitamin B12 and cervical human      

           papilloma virus (HPV) infection with squamous intraepithelial lesions

            Abike F, Engin AB, Dunder I, Kutluay L (Ankara, Turkey)


4:35 – 5:00      Coffee Break


5:00 – 6:40      Chair: Fuith LC (Eisenstadt, Austria)

Computer simulations in structural biology - what is it good for?

            Teigen K, Martinez A, Case D (Bergen, Norway)

5:20     Effects of type I and type II interferons on neopterin and amino acid metabolism in human

            astrocyte-derived cell lines

            Neurauter G, Cano OD, Fuchs D, He JJ, Shearer GM, Boasso A (Innsbruck, Austria; Indianapolis, IN & 

            Bethesda, MD, USA)

5:40     Cannabinoids inhibit mitogen-induced tryptophan degradation and neopterin formation in 

            peripheral blood mononuclear cells in vitro

            Jenny M, Santer E, Schennach H, Pirich E, Fuchs D (Innsbruck & Vienna, Austria)

6:00     Cannabinoids influence tryptophan degradation and neopterin formation in LPS-induced

            myelomonocytic THP-1 cells

            Santer E, Jenny M, Pirich E, Ledochowski M, Ueberall F, Fuchs D (Innsbruck, Austria)

6:20     Effect of propolis extracts on neopterin production and tryptophan degradation in stimulated 

            human PBMC

            Girgin G, Ledochowski M, Bolukbasi ND, Sorkun K, Salih B, Sahin G, Baydar T, Fuchs D (Ankara, Turkey; 

            Innsbruck, Austria


Wednesday, March 5th, 2008                   9:00 a.m. - 1:00 p.m.: Meet the Experts

                                                                                    3:15 p.m. - 6:55 p.m.: Scientific Sessions

3:15 – 4:45      Chair: Mistrik M (Bratislava, Slovakia)

3:15     Patterns of DAMPs and PAMPs mediated biomarkers for posttraumatic monitoring

            Faist E, Zedler S (Munich, Germany)

3:45     Monitoring of selected immunologic markers in patients with severe burn injury

            Zedler S, Faist E (Munich, Germany)

4:05     Neopterin induces NF-kB expression in transformed myelomonocytic THP-1 cells

            Jenny M, Ledochowski M, Ueberall F, Fuchs D (Innsbruck, Austria)

4:25     T cell responses and tryptophan metabolism in ANCA associated vasculitis

            Chavele KM, Fuchs D, Arapchi T, Shukla D, Pusey C, Salama A (London, UK; Innsbruck, Austria)


4:45 – 5:15      Coffee Break


5:15 – 6:35      Chair: Pellegrin K (Los Angeles, CA, USA)

5:15     Hematology disorders and plasma neopterin

            Mistrík M, Parrák V, Šujanová Z, Skraková M, Zwiewka M, Fuchs D (Bratislava, Slovakia; Innsbruck, Austria)

5:35     Correlation of plasma neopterin levels and malignant disease activity in children

        Parrak V, Puskacova J, Mistrik M, Secnik P, Behulova D, Laluhova-Striezencova Z, Kolenova A, Fuchs D

          (Bratislava, Slovakia; Innsbruck, Austria)

 5:55    Plasma cytokine changes induced by the antitumor agent dipterinyl calcium pentahydrate (DCP) and 

            related calcium pterins

            Moheno P, Pfleiderer W, Fuchs D (La Jolla, CA, USA; Konstanz, Germany; Innsbruck, Austria)

 6:15    Evidence on the direction of effects between day-to-day changes in cellular immune activation,

            fatigue and mood in two patients with prior breast cancer: A time-series analysis approach

            Schubert C, Burbaum C, Neises M, Geser W, Ocaña-Peinado FM, Fuchs D, Schmid-Ott G, Fritzsche K 

            (Innsbruck, Austria; Freiburg & Hannover, Germany; Granada, Spain)

6:35     The importance of neopterin testing for diagnostics

            Nikishova N, Dashkova N, Ragimov A (Moscow, Russia)


Thursday, March 6th, 2008                                     9:00 a.m. - 1:00 p.m.: Meet the Experts

                                                                                    3:15 p.m. - 5:40 p.m.: Scientific Sessions

                                                                                             5:40 p.m.: General Assembly of ISP


3:15 – 4:45      Chair: Hoffmann G (Hall, Austria)

3:15     Increased expression of indoleamine 2,3-dioxygenase in oral squamous cell carcinomas 

            contributes to response to adjuvant therapy and overall survival

Brandacher G, Kronberger IE, Laimer K, Perathoner A, Fuchs D, Amberger A (Innsbruck, Austria)

3:35     NOS cofactor activity of BH4 is essential for IRI attenuation following murine pancreas 


            Maglione M, Oberhuber R, Hengster P, Hermann M, Schneeberger S, Mark W, Obrist P, 

            Werner-Felmayer G, Margreiter R, Werner ER, Brandacher G (Innsbruck, Austria)

3:55     Does neopterin influence ciliary beat frequency of nasal epithelial cells in vitro?

            Schobersberger W, Hoffmann G, Fuchs D, Neher A (Hall & Innsbruck, Austria)

4:15     Seasonal variation of neopterin concentrations in blood donations

            Mayersbach P, Fuchs D, Schennach H (Innsbruck, Austria)


4:35 – 5:00      Coffee Break


5:10 – 5:45      Chair: Schennach H (Innsbruck, Austria)

5:00     Neopterin and mortality in the Ludwigshafen Risk and Cardiovascular (LURIC) Health Study

            Grammer TB, Fuchs D, Seelhorst U, Wellnitz B, Rose DM, Winkelmann BR, Boehm BO, März W (Graz & 

            Innsbruck, Austria; Freiburg, Mainz, Frankfurt am Main, Ulm, Germany & Heidelberg, Germany)

5:20     Differences and similarities of C-reactive protein and neopterin as diagnostic parameters

            Murr C, Grammer T, Boehm BO, Winkelmann BR, März W, Fuchs D  (Innsbruck, Austria; Heidelberg, Ulm & 

            Frankfurt am Main, Germany)

5:40     Annual General Assembly of the International Society of Pteridinology (ISP)

            (ISP members only)

Friday, March 7th, 2008                                    9:00 a.m. - 1:00 p.m.: Meet the Experts

                                                                                    3:15 p.m. - 6:55 p.m.: Scientific Sessions


3:15 – 4:35      Chair:  Zangerle R (Innsbruck, Austria)

3:15     Chronic innate immune activation as a cause of HIV-1 immunopathogenesis

            Boasso A, Hardy A, Fuchs D, Landay A, Martinson J, Clerici M, Shearer GM (London, UK;

            Ft. Washington, PA; Innsbruck, Austria; Chicago, IL; Milano, Italy; Bethesda, MD, USA)

3:45     Indoleamine 2,3-dioxygenase in human hematopoietic stem cell transplantation

            Juergens B, Hainz U, Heitger A (Vienna, Austria)

4:05     Accelerated tryptophan degradation predicts poor survival in trauma and sepsis patients

            Ploder M, Spittler A, Schroecksnadel K, Neurauter G, Pelinka L, Roth E, Fuchs D (Vienna & Innsbruck, 


4:25     Impact of indoleamine 2,3-dioxygenase (IDO) mediated tryptophan metabolism on tumor cell growth

            Troester B, Fuchs D, Obexer P, Moser P, Margreiter R, Brandacher G, Amberger A (Innsbruck, Austria)


4:45 – 5:15      Coffee Break


5:15 – 6:35      Chair: Werner-Felmayer G (Innsbruck, Austria)

5:15     Release of volatile organic compounds (VOCs) from the lung cancer cell lines A549 and 

            NCI-H2087 in vitro: possible use as tumor markers

            Sponring A, Mikoviny T, Wiesenhofer H, Filipiak W, Ligor T, Ligor M, Amann A, Troppmair J 

            (Innsbruck, Austria)

5:35     Protein motifs in tetrahydrobiopterin-dependent enzymes

            Werner ER, Watschinger K, Keller MA, Golderer G, Werner-Felmayer G (Innsbruck, Austria)

5:55     Properties of tetrahydrobiopterin-dependent glyceryl ether monooxygenase activity in

            rat liver microsomes

            Watschinger K, Keller MA, Hermetter A, Prast H, Golderer G, Werner-Felmayer G, Werner ER 

            (Innsbruck & Graz, Austria)

6:15     Fate of long-chain fatty aldehydes in rat liver microsomes

            Keller MA, Watschinger K, Hermetter A, Golderer G, Werner-Felmayer G, Werner ER

            (Innsbruck & Graz, Austria)

6:35     Glyceryl ether monooxygenase update

Werner ER, Hermetter A, Prast H, Golderer G, Werner-Felmayer G (Innsbruck & Graz, Austria)


Saturday, March 8th, 2008                                         9:00 a.m. - 1:00 p.m.: Meet the Experts

                                                                                    3:15 p.m. - 6:20 p.m.: Scientific Sessions

3:15 – 4:35 Chair: Haeger M (Gothenburg, Sweden)


3:15     Effect of comorbidity on urinary neopterin in patients with breast carcinoma

            Melicharová K, Kalábová H, Krčmová L, Urbánek L, Solichová D, Melichar B (Hradec Králové & Olomouc, 

            Czech Republic)

3:35     Urinary neopterin, hemoglobin and iron metabolism in breast carcinoma patients treated with

            dose-dense chemotherapy

            Melichar B, Urbánek L, Krčmová L, Kalábová H, Melicharová K, Veselý P, Malířová E, Hornychová H, 

            Ryška A, Solichová S (Hradec Králové & Olomouc, Czech Republic)

3:55     Neopterin concentrations and tryptophan degradation in patients with thyroid disease

            Girgin G, Ledochowski M, Sahin TT, Yuksel O, Taneri F, Baydar T, Fuchs D (Ankara, Turkey; Innsbruck, 


4:15     War in Iraq – from a surgical point of view

            Pellegrin K (Los Angeles, CA, USA)


4:35 – 5:00      Coffee Break


5:00 – 6:20      Chair: Fuchs D (Innsbruck, Austria)

5:00     Urinary neopterin during cetuximab therapy

            Melichar B, Urbánek L, Krčmová L, Králíčková P, Kalábová H, Melicharová K, Veselý P, Solichová D (Hradec 

            Králové & Olomouc, Czech Republic)

5:20     Increased asymmetric dimethylarginine (ADMA) concentrations coincide with immune activation in 

            HIV-infected patients

            Schroecksnadel K, Teerlink T, Sarcletti R, Bellmann-Weiler R, Weiss G, Zangerle R, Fuchs D (Innsbruck, 

            Austria; Amsterdam, The Netherlands)

5:40     ApoE genotype and neopterin concentrations in patients with dementia

            Leblhuber F, Beran M, Wichart I, Schroecksnadel K, Brunschuetz D, Fuchs D (Linz, Vienna & Innsbruck, 


6:00     Tryptophan degradation in patients with pollinosis before and after specific immunotherapy

            Kofler H, Grander G, Fuchs D (Hall & Innsbruck, Austria)

6:20     Blair-Curtius-Pfleiderer-Wachter AWARD for Pteridine Research

Closing remarks


The 27th Winterworkshop on "Clinical, Chemical, and Biochemical Aspects of Pteridines" is sponsored by (as by February 1st, 2008):



Novato (CA, USA)



Vienna (Austria)


B.R.A.H.M.S. Diagnostica

Hennigsdorf-Berlin (Germany)


HYPO-BANK, Zweigstelle Univ.-Klinik

Innsbruck (Austria)


IBL-Immuno Biological Laboratories

Hamburg (Germany)



Berlin - Munich (Germany)


VWR International GmbH

Vienna (Austria)